rename columns pandas

df = df.rename(columns = {'myvar':'myvar_new'})

>>> df = pd.DataFrame({"A": [1, 2, 3], "B": [4, 5, 6]})
>>> df.rename(columns={"A": "a", "B": "c"})
   a  c
0  1  4
1  2  5
2  3  6